Small bowel enteropathy associated with olmesartan medoxomil treatment

Δείτε το αρχείο http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2767  
Φορέας Ελληνική Γαστροεντερολογική Εταιρία
Συλλογή Annals of Gastroenterology Small bowel enteropathy associated with
olmesartan medoxomil treatment
Επιμέρους συλλογή Case Report
ΠεριγραφήSprue-like enteropathy associated with treatment with olmesartan medoxomil, an angiotensin II receptor blocker, has been described recently. Herein, we report two patients who developed chronic severe non-bloody diarrhea, weight loss, and muscle wasting after prolonged use of olmesartan. Histologic and immunohistochemical examination of multiple duodenal biopsies revealed severe villous atrophy. Clinical signs ceased upon drug discontinuation. Physicians should be aware of this enteropathy even if olmesartan has been taken for months or years. Whether this adverse event is specific for olmesartan or is a class effect of angiotensin II receptor blockers is currently unknown. To the best of our knowledge, these case reports are the first reported in Greece.Keywords Sprue-like enteropathy, olmesartan, villous atrophyAnn Gastroenterol 2017; 30 (1): 131-133
Δημιουργοί Galanopoulos, Michail Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Varytimiadis, Lazaros Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Tsigaridas, Athanasios Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Karatzas, Pantelis S. Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Archavlis, Emmanuel Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Viazis, Nikos Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Vourlakou, Christina Department of Pathology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece Mantzaris, Gerassimos J. Department of Gastroenterology, “Evaggelismos-Ophthalmiatreion Athinon-Polycliniki”, Athens, Greece
ΕκδότηςAnnals of Gastroenterology
Ημερομηνία2016-12-29
Μορφότυποςapplication/pdf
Μορφότυποςtext/html
ΠηγήAnnals of Gastroenterology; Volume 30, No 1 (2017); 131
Σχέσηhttp://www.annalsgastro.gr/index.php/annalsgastro/article/do
wnload/2767/14559
Σχέσηhttp://www.annalsgastro.gr/index.php/annalsgastro/article/do
wnload/2767/14560
Σχέσηhttp://www.annalsgastro.gr/index.php/annalsgastro/article/do
wnload/2767/14818