Causes and management of chronic hepatitis C in treatment experienced patients

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Φορέας Ελληνική Γαστροεντερολογική Εταιρία
Συλλογή Annals of Gastroenterology Causes and management of chronic hepatitis C in treatment experienced patients
Επιμέρους συλλογή Current views
ΠεριγραφήChronic Hepatitis C is a major public health issue, affecting>2% of the worlds population. Combination treatment with pegylated interferon alfa and ribavirin is successful in achieving long-term viral suppression in about 50% of patients. The ever-growing population of relapsers and non-responders to PEG-IFN + ribavirin poses a difficult clinical problem. We investigate the causes of treatment failure, whether virus-related (HCV genotype, quasispecies diversity and viral load) or host-related (age, sex, race, fibrosis/cirrhosis, obesity and insulin resistance) and review the results of recently published trials on the treatment of relapsers and non-responders to PEG-IFN + ribavirin, focusing on the prognostic value of week 12 HCV-RNA measurements.
Δημιουργοί A. Ilias A. Beltsis
ΕκδότηςAnnals of Gastroenterology
Ημερομηνία2009-10-05
ΤύποςPeer-reviewed Article
Μορφότυποςapplication/unknown
ΠηγήAnnals of Gastroenterology; Vol 22, No 4 (2009)
Επισκέψεις11