Development of non Hodgkin’s lymphoma in a patient with primary biliary cirrhosis: A case report and review of the literature

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Φορέας Ελληνική Γαστροεντερολογική Εταιρία
Συλλογή Annals of Gastroenterology Development of non Hodgkin’s lymphoma in a patient with primary biliary cirrhosis: A case report and review of the literature
Επιμέρους συλλογή Early View
ΠεριγραφήPatients with autoimmune disorders seem to have an elevated risk of lymphoma, especially non-Hodgkin’s lymphoma (NHL). The increased risk has been attributed to the disturbance of immune function found in these patients or to the immunosuppressive therapy used to treat the autoimmune disorders. However, little information exists about the estimated baseline risk for lymphoma in patients with primary biliary cirrhosis (PBC). In this case report, we describe a female patient who developed nodal diffuse large B-cell lymphoma ten years following PBC diagnosis. Twenty five additional case reports (19 NHL and 4 Hodgkin’s disease (HD), 2 without data about NHL or Hodgkin’s disease) predominantly females were identified in the English literature. B-cell lymphoma was the most common NHL type reported but beyond that no clear predisposition for any specific lymphoma subtype was documented. PBC usually preceded lymphoma diagnosis. Fifteen cases had extranodal localization and the most common site was the liver. Keywords PBC, non-Hodgkin’s lymphoma, autoimmune disorders Ann Gastroenterol 2011; 24 (2): 1-4
Δημιουργοί Alexandra Alexopoulou Theoni Kanellopoulou Flora N. Kontopidou Anna Filiotou
ΕκδότηςAnnals of Gastroenterology
Ημερομηνία2011-04-27
ΤύποςPeer-reviewed Article
Μορφότυποςapplication/pdf
ΠηγήAnnals of Gastroenterology; Vol 24, No 2 (2011) - Early View