A randomised controlled trial comparing octreotide vs octreotide plus sclerotherapy in the control of bleeding and early mortality from esophageal varices

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Φορέας Ελληνική Γαστροεντερολογική Εταιρία
Συλλογή Annals of Gastroenterology A randomised controlled trial comparing octreotide vs octreotide plus sclerotherapy in the control of bleeding and early mortality from esophageal varices
Επιμέρους συλλογή Original Articles
ΠεριγραφήSUMMARY Octreotide, the long-acting analogue of somatostatin, has been used as the initial treatment in acute variceal haemorrhage, with conflicting results. In this study we compared octreotide alone with octreotide and sclerotherapy combined in the control of acute variceal bleeding. The mortality within a six-week period after the acute variceal haemorrhage was also examined. In a prospective trial 30 patients with cirrhosis and variceal haemorrhage confirmed by endoscopy, were randomized to two groups (A and B). All patients received octreotide after admission, in a continuous infusion (50�g/h) for five days. The patients of group A underwent variceal sclerotherapy with ethanolanime 5% injection at emergency endoscopy. At 120 hr bleeding was controlled in 100%(15/15) in group A and 93%(14/15) in group B (NS). Mean transfusion requirements were not significantly different between the two groups (group A=2,7 blood units and group B=3,1 blood units). No side effects were detected in either group and no deaths observed. The mortality from bleeding recurrence at six-weeks were: none of group A and 2/15(13%) of group B (NS). In conclusion, the results of this study suggest that a five day course of octreotide alone, without the addition of sclerotherapy appears to be effective in the emergency control of active variceal bleeding in cirrhosis. Key words: Octeotide, Sclerotherapy, Esophageal varices, Bleeding
Δημιουργός D. Kapetanos, A. Ilias, G. Kokozidis, G. Kitis, Th. Patsanas, N. Kousopoulou,
ΕκδότηςAnnals of Gastroenterology
Ημερομηνία2007-03-19
Μορφότυποςapplication/pdf
ΠηγήAnnals of Gastroenterology; Volume 15, No 2 (2002)