Advances in genetics of IBD: the NOD2/CARD15 gene

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Φορέας Ελληνική Γαστροεντερολογική Εταιρία
Συλλογή Annals of Gastroenterology Advances in genetics of IBD: the
NOD2/CARD15 gene
Επιμέρους συλλογή Reviews
ΠεριγραφήDuring the last few years, significant advances have been achieved in the understanding of the pathogenesis of inflammatory bowel diseases (IBD). By gaining new insights, paradigms that seemed to be a safe basis of our knowledge on IBD genetics have recently become doubtful. This review discusses and summarizes recent developments in IBD genetics. Genetic factors play an important role in the pathogenesis of IBD, including both ulcerative colitis (UC) and Crohn�s disease (CD). IBD, are characterized by an abnormal mucosal immune response to enteric flora in genetically susceptible individuals. It seems that they comprise complex genetic disorders with multiple contributing genes. Recent linkage studies have implicated several genomic regions as likely to containing IBD susceptibility genes, some observed uniquely in CD or UC, and others common to both disorders. The best replicated linkage region, IBD1 (16q12), contains the CD susceptibility gene, NOD2/CARD15. Key words: IBD, NOD2/CARD15 gene, genetics, Crohn�s disease, ulcerative colitis.
Δημιουργός Kollias, root
ΕκδότηςAnnals of Gastroenterology
ΠηγήAnnals of Gastroenterology; Volume 18, No 4 (2005)