|Περιγραφή||During the last few years,
significant advances have been achieved in the understanding of the
pathogenesis of inflammatory bowel diseases (IBD). By gaining new
insights, paradigms that seemed to be a safe basis of our knowledge
on IBD genetics have recently become doubtful. This review
discusses and summarizes recent developments in IBD genetics.
Genetic factors play an important role in the pathogenesis of IBD,
including both ulcerative colitis (UC) and Crohn�s disease (CD).
IBD, are characterized by an abnormal mucosal immune response to
enteric flora in genetically susceptible individuals. It seems that
they comprise complex genetic disorders with multiple contributing
genes. Recent linkage studies have implicated several genomic
regions as likely to containing IBD susceptibility genes, some
observed uniquely in CD or UC, and others common to both disorders.
The best replicated linkage region, IBD1 (16q12), contains the CD
susceptibility gene, NOD2/CARD15. Key words: IBD, NOD2/CARD15 gene,
genetics, Crohn�s disease, ulcerative colitis.|