Current advances of genetics in Inflammatory Bowel Disease

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Φορέας Ελληνική Γαστροεντερολογική Εταιρία
Συλλογή Annals of Gastroenterology Current advances of genetics in
Inflammatory Bowel Disease
Επιμέρους συλλογή Lecture
ΠεριγραφήGenetic factors play an important role in the pathogenesis of inflammatory bowel diseases (IBD), including both ulcerative colitis (UC) and Crohn’s disease (CD). The research on genetic susceptibility of IBD has been tremendous and over 10 chromosomal regions have been identified by genome-wide scanning. The certain replicated linkage region in different studies, IBD1 (16q12), contains the CD susceptibility gene, NOD2/CARD15. Further fine mapping as well as candidate gene studies have already led to the identification of a number of other susceptibility genes including DLG5, OCT1 and 2, NOD1, HLA, and TLR4. Recent studies, particularly in CD, have highlighted a number of associations between genotype and phenotype. These, suggest that genetics also may influence the clinical manifestations of IBD including disease location, behavior, natural history and side effects of drug therapy. Genetic research in IBD has helped our understanding of the clinical heterogeneity of the disease and has started to explore the complex interactions between genetic risk factors and environmental risk factors in IBD. Although rapid advances in genomic medicine are yet to impact on routine clinical practice, it is anticipated that genetic markers in the future will be implemented in an integrated molecular diagnostic, therapeutic and prognostic approach of IBD patients.
Δημιουργός Economou, M.
ΕκδότηςAnnals of Gastroenterology
ΠηγήAnnals of Gastroenterology; Volume 19, No 2 (2006)