Chronic hepatitis C: immune disturbances from peripheral blood

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PhD thesis (EN)

2009 (EN)
Χρόνια ηπατίτιδα C: ανοσολογικές διαταραχές εκ του περιφερικού αίματος
Chronic hepatitis C: immune disturbances from peripheral blood

Γραμματικός, Αλέξανδρος Φ.

Although several studies have pointed to an important Treg cell role inchronic hepatitis C immunopathogenesis, the question which cell types are targeted in particular has not been addressed yet. Based on the hypothesis that Treg cells are related to immunosuppression and the development of chronicity in HCV infection we evaluated the effect Treg cells have on particular lymphocyte subpopulations in HCV infected patients. In particular, there is profound failure to generate high numbers of mature effector CD8+ T cells in chronic HCV, thus we hypothesized that inhibition of proliferation and associated maturation of CD8+ T cells might be most significantly affected. In parallel we attempted to evaluate a possible immune regulatory role of B lymphocytes in chronic hepatitis C patients
Σκοπός της παρούσας μελέτης ήταν να μελετήσουμε το ρόλο που διαδραματίζουν τα Treg λεμφοκύτταρα κατά τη χρόνια λοίμωξη από τον ιό της ηπατίτιδας C σε σχέση με τα υγιή άτομα και να αναλύσουμε την επίδραση αυτών των κυττάρων σε διαφορετικούς υποπληθυσμούς λεμφοκυττάρων. Παράλληλος στόχος ήταν η ανάλυση των φαινοτυπικών δεικτών και της ικανότητας έκκρισης αντιικών κυτταροκινών των κεντρικών και εκτελεστικών λεμφοκυττάρων μνήμης του περιφερικού αίματος των χρόνιων ασθενών, όπως και η αναζήτηση πιθανού ανοσοτροποποιητικού ρόλου των Β λεμφοκυττάρων στους ασθενείς αυτούς

PhD Thesis / Διδακτορική Διατριβή

T ρυθμιστικά λεμφοκύτταρα
Immune disturbances
CD62+ T central memory cells
T cells
Ανοσολογική μνήμη
CD62+ T κεντρικά λεμφοκύτταρα
Immune regulations
CD8+ T lymphocytes
Immunologic memory
Hepatitis C
Ηπατίτιδα C
CD8+ λεμφοκύτταρα
Κύτταρα Τ

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)



Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

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