Antineoplastic and cytogenetic effects of complexes of Pd(II) with 4N-substituted derivatives of 2-acetyl-pyridine-thiosemicarbazone

 
see the original item page
in the repository's web site and access all digital files if the item*
share




1997 (EN)
Antineoplastic and cytogenetic effects of complexes of Pd(II) with 4N-substituted derivatives of 2-acetyl-pyridine-thiosemicarbazone

Mourelatos, Dionysios
Mioglou-Kalouptsi, Eleftheria
Kovala-Demertzi, D.
Kotsis, Alexandros
Dermetzis, MA.
West, DX.
Boutis, Lazaros
Domopoulou, A.
Papageorgiou, Athanasios
Iakovidou-Kritsi, Zafeiroula

The effect of novel Pd(II) complexes with derivatives of 2-acetyl-pyridinethisemicarbazone, N4-ethyl (HAc4Et) and 3-hexamethyleneiminylthiosemicarbazone (HAchexim), on Sister Chromatid Exchange (SCE) rates and human lymphocyte proliferation kinetics was studied. Also, the effect of Pd(II) complexes on DNA synthesis of P388 and L1210 cell cultures and against Leukemia P388 was investigated. Among these compounds, the compound Bis(3-hexamethyleneiminyl-2-acetylpyridine-thisemicarbazonato++ +) palladium (II) was found to be distinctly effective against Leukemia P388, in inhibiting incorporation of 3H-thymidine into DNA and in inducing SCEs and cell division delays.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

English

1997
2009-07-17T08:59:03Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Anticancer Research, vol.17 no.1A [1997] p.247-251 [Published Version]
urn:ISSN:02507005

This record is part of 'IKEE', the Institutional Repository of Aristotle University of Thessaloniki's Library and Information Centre found at http://ikee.lib.auth.gr. Unless otherwise stated above, the record metadata were created by and belong to Aristotle University of Thessaloniki Library, Greece and are made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). Unless otherwise stated in the record, the content and copyright of files and fulltext documents belong to their respective authors. Out-of-copyright content that was digitized, converted, processed, modified, etc by AUTh Library, is made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). You are kindly requested to make a reference to AUTh Library and the URL of the record containing the resource whenever you make use of this material.
info:eu-repo/semantics/openAccess



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)