Comparative study of sister chromatid exchange induction and antitumor effects by homo-aza-steroidal esters of {p-[bis(2-chloroethyl)amino]phenyl}butyric acid

 
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2001 (EN)
Comparative study of sister chromatid exchange induction and antitumor effects by homo-aza-steroidal esters of {p-[bis(2-chloroethyl)amino]phenyl}butyric acid

Mourelatos, Dionysios
Karayianni, V.
Mioglou-Kalouptsi, Eleftheria
Catsoulacos, D.
Camoutsis, C.
Nikolaropoulos, S.
Papageorgiou, Athanasios
Iakovidou-Kritsi, Zafeiroula

The present work was undertaken in order to test the hypothesis that the Sister Chromatid Exchange (SCE) assay in vitro can be used for the prediction of in vivo tumor response to newly synthesized potential chemotherapeutics. The effect of three homo-aza-steroidal esters containing the -CONH- in the steroidal nucleus, 1, 2, and 3 on SCE rates and on cell kinetics in cultured human lymphocytes was studied. The antitumor activity of these compounds was tested on leukemia P388- and leukemia L1210-boaring mice, The three substances induced statistically significant enhancement of SCF, and of cell division delays, Compounds 1 and 3 were identified, on a molar basis, as more effective inducers of SCEs and of cell division delays compared with compound 2. Compounds 1 and 3 had upon both experimental tumors, better therapeutic effects compared with compound 2 at equitoxic closes. Therefore, the order of the antitumor effectiveness of the three compounds coincided with the order of the cytogenetic effects they induced.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

English

2001
2009-07-17T10:31:19Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Cancer Detection and Prevention, vol.25 no.6 [2001] p.558-564 [Published Version]
urn:ISSN:0361090X

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