Induction of sister-chromatid exchanges in heroin-cannabis, heroin and cannabis addicts

 
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1986 (EN)
Induction of sister-chromatid exchanges in heroin-cannabis, heroin and cannabis addicts

Mourelatos, Dionysios
Dozi-Vassiliades, J.
Chatzitheodoridou, Pinelopi
Vasileiadis, Nikolaos
Epivatianos, P.

The aim of this study was to determine the frequency of sister-chromatid exchanges (SCEs) in heroin-cannabis, heroin and cannabis addicts. The group of 84 subjects consisted of 42 controls, 16 heroin-cannabis addicts, 12 heroin addicts and 14 cannabis addicts. The mean number of SCEs/cell was 12.95 in heroin-cannabis addicts, 12.05 in heroin addicts and 11.99 in cannabis addicts. These values are significantly (P less than 0.002) higher than the mean values found in controls. This increase in SCEs may be related to reduced DNA repair in chronic drug addicts, which would allow the fixation or retention of a greater fraction of the DNA lesions caused by normal environmental exposure

Article / Άρθρο
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Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

English

1986
2009-07-17T10:38:11Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Mutation Research, vol.170 [1986] p.125-127 [Published Version]
urn:ISSN:01651110

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