Synergistic antitumor activity of oxaliplatin in combination with gemcitabine in pancreatic tumor-bearing mice

 
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Synergistic antitumor activity of oxaliplatin in combination with gemcitabine in pancreatic tumor-bearing mice

Mourelatos, Dionysios
Charlaftis, Nikolaos
Atmatzidis, Konstantinos
Chrysogelou, Eleni
Tsalis, Konstantinos
Moschidis, E.
Tsavdaridis, Dimitrios
Moschidis, A.
Papageorgiou, Athanasios
Livanis, J.

Oxaliplatin (OX) and gemcitabine (GEM) are both drugs with proven clinical activity in various tumor types, have no overlapping toxic side effects and are different with respect to cellular metabolism. Therefore, we performed an in vivo study to determine the efficacy of the combination of these two drugs to optimize the scheduling of both substances using pancreatic ductal adenocarcinoma PAN-02, subcutaneously growing in C57Bl mice. A total of 164 mice were used for cytotoxicity and antitumor studies. The combination therapy resulted in better results than those observed when the drugs were administered individually. GEM (58 mg/kg) and OX (1.0 mg/kg) achieved a 52% reduction in tumor size on day 28 after transplantation and a T/C value of 168% when the intermittent treatment schedule on days 1, 4 and 7 after inoculation was used. This treatment schedule was superior to other therapeutic schedules, producing a synergistic antitumor effect much higher than the one expected by the simple addition of the effects by OX and GEM acting independently. Copyright (c) 2007 S. Karger AG, Basel

Article / Άρθρο
info:eu-repo/semantics/article

Adenocarcinoma
Mice, Inbred C57BL
Organoplatinum Compounds
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Male
Drug Synergism
Xenograft Model Antitumor Assays
Animals
Deoxycytidine
Female
Mice
Pancreatic Neoplasms

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

2007
2009-07-17T11:01:23Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Chemotherapy, vol.53 no.3 [2007] p.153-159 [Published Version]
urn:ISSN:00093157

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info:eu-repo/semantics/openAccess



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