A comparative study of the cytogenetic and antineoplastic effects induced by steroidal amidoesters of p-N,N-bis (2-chloroethyl) aminophenylbutyric acid (chlorambucil)
The effect of four stereoisomers of steroidal amidoesters with p-N, N-bis (2-chloroethyl)aminophenylbutyric acid (Chlorambucil) has been tested on sister chromatid exchanges (SCE) and on human lymphocyte proliferation kinetics, A correlation was observed in this group of four compounds between the magnitude of the SCE response and the depression in the proliferation rate index, The antitumour activity of the same compounds was tested on leukemia P388-bearing mice and on DNA synthesis of P388 and L1210 leukemia cell cultures, We observed that the order of the antitumour effectiveness of the four-compounds tested coincided with the order of the cytogenetic effects they induced.
Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής
Cancer Journal, vol.9  p.203-206 [Published Version]
This record is part of 'IKEE', the Institutional Repository of Aristotle University of Thessaloniki's Library and Information Centre found at http://ikee.lib.auth.gr. Unless otherwise stated above, the record metadata were created by and belong to Aristotle University of Thessaloniki Library, Greece and are made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0).
Unless otherwise stated in the record, the content and copyright of files and fulltext documents belong to their respective authors. Out-of-copyright content that was digitized, converted, processed, modified, etc by AUTh Library, is made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). You are kindly requested to make a reference to AUTh Library and the URL of the record containing the resource whenever you make use of this material.
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.