Synthesis and cytogenetic studies of structure-biological activity relationship of esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers

 
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2005 (EN)
Synthesis and cytogenetic studies of structure-biological activity relationship of esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers

Mourelatos, Dionysios
Mioglou-Kalouptsi, Eleftheria
Pairas, G.
Gasparinatou, C.
Camoutsis, Charalambos
Iakovidou-Kritsi, Zafeiroula

The esters of Hecogenin and aza-homo-Hecogenin with NN-bis(2-chloroethyl)aminocinnamic acid isomers have been prepared and their cytogenetic studies of structure-biological activity relationship were evaluated. The cytogenetic effects (sister chromatid exchages (SCEs) induction and proliferation rate indices (PRIs) depression) by o-, m- and p-[NN-bis(2-chloroethyl)amino] cinnamic acid were also investigated. Among the above compounds tested, those of the m-[NN-bis(2-chloroethyl)amino] cinnamic acid and of the o-[NN-bis(2-chloroethyl)amino] cinnamic acid ester of aza-homo-Hecogenin were more active in comparison to the others. (c) 2005 Elsevier Inc. All rights reserved.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

English

2005
2009-07-17T11:16:38Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

urn:ISSN:0039128X
Steroids, vol.70 [2005] p.586-593 [Published Version]

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