A comparative study on cytogenetic and antineoplastic effects induced by two modified steroidal alkylating agents

 
see the original item page
in the repository's web site and access all digital files if the item*
share




2001 (EN)
A comparative study on cytogenetic and antineoplastic effects induced by two modified steroidal alkylating agents

Mourelatos, Dionysios
Chrysogelou, Eleni
Kotsis, Alexandros
Geromichalos, Georgios D.
Houvartas, S.
Tsavdaridis, Dimitrios
Papageorgiou, Athanasios
Karamperis, Stergios
Camoutsis, Charalambos

We investigated the effects of two newly synthesized steroidal derivatives of nitrogen mustard on sister chromatid exchange rates and on human lymphocyte proliferation kinetics. The compound 3 beta -hydroxy-5 alpha ,22 alpha -spirostan-12-one-p-(N,N-bis(2-chloroethyl)amino)phenylacetate(1) was. on a molar basis, less effective in inducing sister chromatid exchange and suppressing cell proliferation rate indices than compound 3 beta -hydroxy-12 alpha -aza-C-homo-5 alpha ,22 alpha -spirostan-12-one-p-(N,N-bis(2-chloroethyl)amino)phenylacetate(2). A correlation was observed between the magnitude of the sister chromatid exchange response and the depression of cell proliferation index. We also studied the effects of the aforementioned compounds on Lewis lung carcinoma. The order of the percent inhibition of tumor growth achieved by the compounds coincides with the order of the cytogenetic effects they induce.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

2001
2009-07-17T11:23:46Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Cancer Detection and Prevention, vol.25 [2001] p.369-374 [Published Version]
urn:ISSN:0361090X

This record is part of 'IKEE', the Institutional Repository of Aristotle University of Thessaloniki's Library and Information Centre found at http://ikee.lib.auth.gr. Unless otherwise stated above, the record metadata were created by and belong to Aristotle University of Thessaloniki Library, Greece and are made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). Unless otherwise stated in the record, the content and copyright of files and fulltext documents belong to their respective authors. Out-of-copyright content that was digitized, converted, processed, modified, etc by AUTh Library, is made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). You are kindly requested to make a reference to AUTh Library and the URL of the record containing the resource whenever you make use of this material.
info:eu-repo/semantics/openAccess



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)