Enhancement of cytogenetic damage and of antineoplastic effect in lymphoid L1210 leukemia cells treated with prostaglandin E2 and cyclophosphamide in vivo

 
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Enhancement of cytogenetic damage and of antineoplastic effect in lymphoid L1210 leukemia cells treated with prostaglandin E2 and cyclophosphamide in vivo

Mourelatos, Dionysios
Mioglou-Kalouptsi, Eleftheria
Dozi-Vassiliades, J.
Iakovidou-Kritsi, Zafeiroula

An enhanced frequency of sister-chromatid exchanges (SCEs) and increased cell division delays induced by cyclophosphamide (CP) were observed when lymphoid L1210 leukemia cells were post-treated in vivo with prostaglandin E2 (PGE2). CP gave a slight, non-significant increase in survival while PGE2 gave a slight, non-significant decrease in survival. However, PGE2 in combination with CP was found to have a non-significant potentiating effect on survival in comparison with mice treated with CP alone. In mice treated with the combined CP (5 mu g/g b.w.) plus PGE2 (2 mu g/g b.w.) treatment, a significant (P < 0.01) enhancement of survival time in comparison with the untreated controls was observed.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

Αγγλική γλώσσα

1995
2009-07-17T11:25:45Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

urn:ISSN:00275107
Mutation Research-Fundamental and Molecular mechanisms of Mutagenesis, vol.326 [1995] p.125-129 [Published Version]

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info:eu-repo/semantics/openAccess



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