Cytogenetic damage by melphalan and hyperthermia in patients with an initial epileptic attack

 
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Cytogenetic damage by melphalan and hyperthermia in patients with an initial epileptic attack

Mourelatos, Dionysios
Petridou, M.
Routsonis, Kornelios
Kazis, Aristeidis
Kosta-Tsolaki, Magdalini
Kourakis, Anastasios

Sister-chromatid exchanges (SCEs) and cell kinetics in cultured lymphocytes of patients with an initial epileptic attack, and prior to any anticonvulsant treatment, were studied. Spontaneous melphalan (MEL) and MEL-hyperthermia (MEL-HYP) induced SCE frequencies have been studied in 18 adults with an initial epileptic seizure. Fifteen age and sex matched healthy subjects were used as the control group. The incidence of spontaneous SCEs in lymphocytes from epileptics was not significantly greater than in those from the control subjects. However, when exposed to MEL in vitro, cells from both groups showed an increase in SCE frequency. When exposed to MEL and HYP (41-degrees-C for 3 h) in vitro, cells from both groups showed a further increase in SCE frequency with yields from epileptics higher (P < 0.05) than from controls. HYP in combination with MEL enhanced synergistically SCEs and cell division delays in both groups with synergistic effects in cells from epileptics (P < 0.01 and P < 0.01 respectively) higher than from controls (P < 0.05 and P < 0.05 respectively).

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

1992
2009-07-17T11:29:24Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

urn:ISSN:01651110
Mutation Research/Genetic Toxicology, vol.280 [1992] p.143-148 [Published Version]

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info:eu-repo/semantics/openAccess



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