Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure-activity correlation

 
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Synthesis, characterization, toxicity, cytogenetic and in vivo antitumor studies of 1,1-dithiolate Cu(II) complexes with di-, tri-, tetra- amines and 1,3-thiazoles. Structure-activity correlation

Mourelatos, Dionysios
Mioglou-Kalouptsi, Eleftheria
Chrysogelou, Eleni
Chaviara, AT.
Bolos, Christos
Papageorgiou, Athanasios
Iakovidou-Kritsi, Zafeiroula

A series of new mixed-ligand neutral copper(II) complexes of the general type [Cu(amine)(i-MNT)] and [Cu(tz)(i-MNT)] was prepared and characterized by elemental, spectroscopic methods, mu(eff), Lambda(mu) measurements and molecular modeling studies. The acute toxicity, the cytogenetic and the in vivo antitumor activity of the new complexes, is related to their chemical and physicochemical properties. Among the Cu(II) compounds tested the complex with 2-amino-5-methyl thiazole increases significantly the life span of leukemia P388 bearing mice in vivo. (C) 2009 Elsevier Ltd. All rights reserved.

Article / Άρθρο
info:eu-repo/semantics/article

Amines
Leukemia P388
Humans
Mice, Inbred C57BL
Antineoplastic Agents
Models, Molecular
Male
Structure-Activity Relationship
Organometallic Compounds
Animals
Spectrophotometry, Infrared
Lymphocytes
Thiazoles
Sister Chromatid Exchange
Female
Ligands
Mice, Inbred DBA
Mice
Copper
Sulfhydryl Compounds

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

2009
2009-07-17T11:36:55Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Θετικών Επιστημών, Τμήμα Χημείας
Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Bioorganic and Medicinal Chemistry, vol.17 no.8 [2009] p.3142-3151 [Published Version]
urn:ISSN:09680896

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info:eu-repo/semantics/openAccess



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