Pharmacochemical study of the relatioship between biological and oxidative stress: synthesis of novel compounds with multiple actions against consequenses of stress

 
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PhD thesis (EN)

2009 (EN)
Φαρμακοχημική διερεύνηση της σχέσης βιολογικού και οξειδωτικού στρες
Pharmacochemical study of the relatioship between biological and oxidative stress: synthesis of novel compounds with multiple actions against consequenses of stress

Τσιακιτζής, Καρυοφύλλης Χρ.

Στη διατριβή αυτή μελετώνται οι μορφολογικές και βιοχημικές αλλαγές που λαμβάνουν χώρα στον οργανισμό και κυρίως στο ΚΝΣ κατά τη διάρκεια του Στρες, καθώς και ο αλληλοεπηρεασμός τους. Οι αλλαγές αυτές εξηγούν την απόκριση στρες με σκοπό την αποτελεσματική αντιμετώπιση της πρόκλησης. Μεταξύ των αλλοιώσεων οι οποίες επέρχονται σε περίπτωση μακροχρόνιας έκθεσης του οργανισμού σε συνθήκες Στρες περιλαμβάνονται η εμφάνιση διέγερσης, άγχους, μελαγχολίας, γαστρεντερικού έλκους αλλά και έκπτωση ανωτέρων λειτουργιών του εγκεφάλου, ελάττωση της αντίστασης σε παθογόνους μικροοργανισμούς ή καρκίνος.
The biological phenomenon of stress is certainly older than man. However, it was Hans Selye who described and analyzed it scientifically in a number of different approaches. H. Selye defined biological stress (BS) as: “The non specific response of the body to any demand”. This was accepted by the international scientific community in the ‘70s. The distinction between the specific and the non specific responses of the body to different demands was the most important fact, the decisive step, in the scientific analysis of BS. There are three systems participating, cooperating and mutually influenced in the stress response: The Central Nervous System (CNS), the Endocrine and the Immune system. Following the application of the initial stimulus upon CNS, mediation of the stress response is achieved via: 1) the hypothalamus and the production of CRH (CRF), 2) the action of CRH, via the portal circulation, on the anterior lobe of pituitary and the liberation of ACTH, 3) ACTH acts on the adrenal cortex which produces and secretes corticoids. Thus, there is an activation of Hypothalamic – Pituitary – Adrenocortical (HPA) axis. This axis prepares the body for a long-lasting adaptation. HPA axis is mobilized shortly after the application of stressors. However, even before the HPA axis (few seconds after the application of the stressor), the sympathetic system reacts via catecholamines, as well as, the adrenal medulla with liberation of adrenaline. This Adrenergic – Adrenomedulary axis prepares the body for “fight or flight”

PhD Thesis / Διδακτορική Διατριβή
info:eu-repo/semantics/doctoralThesis

Νευροεκφύλιση
Oxidative stress
Βιολογικό στρες
Oxidative Stress
Biological stress
Stress (Physiology)
Στρες (Φυσιολογία)
Antioxidants, Therapeutic use
Antioxidants
Νοότροπα
Lorazepam
γ-Αμινοβουτυρικό οξύ
Μη στεροειδή
Γλουταθειόνη
Free radicals
Φαρμακευτική χημεία
Αντιφλεγμονώδη,
Λιποϊκό οξύ
Αντιοξειδωτικά
Chemistry, Pharmaceutical
Λιπιδική υπεροξείδωση
Αντιοξειδωτικά, Θεραπευτική χρήση
Ανιρακετάνη
Λοραζεπάνη
NSAIDS
Τρόλοξ
GABA
Οξειδωτικό στρες
Ακυλοπυρρολιδινόνες
Non steroid

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

Greek
English

2009
2009-11-27T09:10:11Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Θετικών Επιστημών, Τμήμα Χημείας

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