Multi-parametric cardiovascular magnetic resonance imaging detects subclinical myocardial involvement in patients diagnosed with phaeochromocytoma

 
δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
κοινοποιήστε το τεκμήριο



Multi-parametric cardiovascular magnetic resonance imaging detects subclinical myocardial involvement in patients diagnosed with phaeochromocytoma

Marini, Claudia
Piechnik, Stefan K
Karavitaki, Niki
Neubauer, Stefan
Hassan-Smith, Zaki
Arlt, Wiebke
Marcelino, Mafalda
Karamitsos, Theodoros
Grossman, Ashley
Arnold, Jayanth R
Francis, Jane M
Thomas, Julia D
Korbonits, Marta
Herincs, Maria
Wass, John
Mihai, Radu
Ferreira, Vanessa M.

Background In patients with phaeochromocytoma, acute or chronic exposure to catecholamines may lead to cardiac pathology, including left ventricular (LV) hypertrophy, myocardial infarction, stress-induced cardiomyopathy and heart failure. The burden of myocardial involvement in this disease with systemic effects is unknown. In this prospective, multicentre study, we sought to describe the variety and incidence of cardiac abnormalities in patients diagnosed with phaeochromocytoma using multi-parametric cardiovascular magnetic resonance (CMR) imaging. Methods We studied 50 patients diagnosed with phaeochromocytoma. Twenty patients (n=20, age 51±14 yrs) newly-diagnosed with confirmed phaeochromocytoma prospectively underwent CMR before and after curative surgical resection of the phaeochromocytoma (median follow-up 1 year). In addition, 30 patients (n=30, age 52±14 yrs) previously diagnosed with phaeochromocytoma who had curative surgery were also recruited for cardiac characterisation. Patients with known cardiac conditions were excluded. CMR included cine imaging for global and regional LV function, dark-blood T2-weighted imaging for oedema and late gadolinium enhancement imaging to detect the presence and patterns of any scarring. Results In patients with newly-diagnosed phaeochromocytoma, the mean LV ejection fraction was 67±10% (EF range 47-88%); of these patients, 20% (n=4/20) had mild global LV dysfunction (EF 47-56%). A significant proportion (65%, n=13/20) demonstrated scarring, all with a non-ischaemic pattern, but these areas were small (<10% myocardium); no patient had evidence of myocardial infarction (isolated subendocardial scarring). One patient demonstrated global myocardial oedema with normal EF. All LV dysfunction or oedema were reversible and normalised at postoperative follow-up. In patients previously-diagnosed who already had had curative surgery, the mean LVEF was essentially normal (73±7%) with only one patient (3%) who had mild global LV dysfunction (EF=56%). Compared to the newly-diagnosed patients, a significantly smaller proportion of previously-diagnosed patients (17% vs. 65%; p<0.001) demonstrated areas of scarring, which were also small in areas with a non-ischaemic pattern, except for one patient who suffered a small myocardial infarction. Conclusions Subclinical cardiac abnormalities are frequent findings on CMR in patients newly-diagnosed with phaeochromocytoma, including mild LV dysfunction, myocardial oedema and small areas of non-ischaemic scarring, with the former two demonstrating normalization after surgical resection of the phaeochromocytoma. In patients who had previously undergone curative surgical resection of their phaeochromocytomas, the incidence of cardiac abnormalities is lower, predominantly consisting of small areas of non-ischaemic fibrosis.

Article / Άρθρο
info:eu-repo/semantics/article

Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (EL)
Aristotle University of Thessaloniki (EN)

Αγγλική γλώσσα

2015
2016-10-12T08:28:10Z


Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Σχολή Επιστημών Υγείας, Τμήμα Ιατρικής

Journal of Cardiovascular Magnetic Resonance, vol.17 no.Suppl 1 [2015] p.P271
urn:ISSN:1532-429X

This record is part of 'IKEE', the Institutional Repository of Aristotle University of Thessaloniki's Library and Information Centre found at http://ikee.lib.auth.gr. Unless otherwise stated above, the record metadata were created by and belong to Aristotle University of Thessaloniki Library, Greece and are made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). Unless otherwise stated in the record, the content and copyright of files and fulltext documents belong to their respective authors. Out-of-copyright content that was digitized, converted, processed, modified, etc by AUTh Library, is made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). You are kindly requested to make a reference to AUTh Library and the URL of the record containing the resource whenever you make use of this material.
info:eu-repo/semantics/openAccess



*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.