Σακχαρώδης διαβήτης και αγγειακά εγκεφαλικά επεισόδεια
The combination of diabetes mellitus and stroke disease is a major cause of increased morbidity and mortality worldwide. Evidence from large clinical trials performed in patients with diabetes support the need for aggressive and early intervention to target patients’ cardiovascular (CV) risks in order to prevent the onset, progression and recurrence of acute stroke in primary and secondary prevention. Identification of at-risk patients with diabetes has also allowed the delivery of early and effective intervention to reduce stroke risks, while active treatment during the acute phase of stroke will reduce long-term neurological and functional deficits. The role of diabetic cardiovascular autonomic neuropathy in the pathogenesis of stroke has been described in the article, also. While the ongoing debate on the risk benefits of different antihypertensive, lipid-lowering and antiplatelet agents should not detract clinicians from pursuing aggressive CV risk reduction, the application of evidence- based medicine specifically in patients with diabetes will facilitate the use of appropriate agents to improve clinical outcomes. The overall management of patients with diabetes and acute stroke or at risk of a recurrent stroke should also include multifactorial intervention that not only targets patient’s CV risk, but also includes behavioural, lifestyle and, where appropriate, surgical intervention.
Article / Άρθρο
Pathogenesis of stroke
Prevention of stroke
Diabetic cardiovascular autonomic neuropathy
Διαβητική νευροπάθεια του αυτόνομου νευρικού συστήματος
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