Aim. To determine if the Granulocyte-Macrophages Colony Stimulating Factor (GM-CSF) could promote the healing of chronic diabetic foot ulcer. These ulcers are a main cause of amputation in patients with Diabetes Mellitus. Description. A 65 year old woman was admitted to the Diabetes Center because of a deep non-healing chronic foot ulcer. The ulcer has been appeared 18th months ago, in the plantar surface of the right foot with diameter 5 cm. Despite the medical efforts the ulcer did not heal. So, GM-CSF treatment was decided in the area of the ulcer. Locally intradermal injections in the hips of the ulcer with GM-CSF (400 mcg two times weekly) were administered for two months. The ulcer healed completely after one year of the beginning of the treatment with GM-CSF. Osteomyelitis excluded with scintigraphy methods. The patient had a history with known Diabetes Mellitus type 2 for 15 years. She had the following complications from diabetes: neuropathy (peripheral and autonomic), retinopathy, nephropathy and Charcot joints in both feet. She had an amputation of the 4th finger of the right foot. She had a history with heart failure also. The patient did not develop clinical side-effects or peripheral blood cell count abnormalities during the treatment. Conclusion. GM-CSF is a safe and effective treatment for chronic non-healing diabetic foot ulcers.
This record is part of 'IKEE', the Institutional Repository of Aristotle University of Thessaloniki's Library and Information Centre found at http://ikee.lib.auth.gr. Unless otherwise stated above, the record metadata were created by and belong to Aristotle University of Thessaloniki Library, Greece and are made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0).
Unless otherwise stated in the record, the content and copyright of files and fulltext documents belong to their respective authors. Out-of-copyright content that was digitized, converted, processed, modified, etc by AUTh Library, is made available to the public under Creative Commons Attribution-ShareAlike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0). You are kindly requested to make a reference to AUTh Library and the URL of the record containing the resource whenever you make use of this material.
*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)