Τοξικότητα υπολιπιδαιμικής αγωγής σε διαβητικούς ασθενείς
Καραμήτσος, Δημήτριος - Σπυρίδων - Έριχ
The aim of the study was to investigate the frequency of hypolipidaemic drugs’ toxicity in diabetic patients. 321 type 2 DM patients were studied retrospectively who had dyslipidaemia and received hypo- lipidaemic treatment in our Diabetes Centre. Elements of patients and their laboratory tests they were recorded in a data base (File Maker Pre 5). Nobody was taken simultaneously two hypolipidaemic medicines. Twenty two individuals received fibrates, one acipimox, and the remaining was taking statins. Results: The medium values and SD of lipids under tre-atment was following: Total Cholesterol 228,55 ±57,76 mg/dl, Trjglycerides 196 ±125,33 mg/dl, HDL 49,56 ±10 mg/ dl, LDL 139,77 ± 68,26 mg/dl. From the 118 pts (36%) that they had increased enzymes of liver the 95 pts (29,6%) they presented also increased values of enzymes before the initiation of hypolipidaemic drugs, because of fatty liver. In 23 pts (7,1%) were observed small increases of hepatic enzymes only under hypolipidaemic treatment. Double increase of enzymes was presented in 26 pts (8,1%) and from them 12 (3,7%) they had increased enzymes before treatment. Triple increase of hepatic enzymes they presented 8 individuals (2,49%) and exclusively to ÁGT. Conclusions: Small increases in enzymes’ concentrations are caused in small percentage of patients who receives hypolipidaemic treatment with statins. Triple increase was observed only in ÁGT. CPK was increased in percentage 6,23% but in no pts was increased more than two times above the normal values. It is considered likely that rabdomyolysis or important hepatic toxicity are infrequent phenomena in patients who undergone in hypolipidaemic monotherapy.
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