The effects of royal jelly on oxidative stress and toxicity caused by malation, an organophosphate insecticide, in tissues
In the present study that aimed to determine the effects of royal jelly on malathion-induced toxicity and biochemical changes. The rats were divided into 6 groups. Control group rats were not treated, while carrier chemicals were administered to sham group rats. Malathion group (MAL) rats were injected with 0.8 g/kg malathion subcutaneously. 100 mg/kg royal jelly was administered with gavage to the rats in the royal jelly group (RJ). 100 mg/kg royal jelly was administered to RJ + MAL group rats via gavage 1 hour before the injection of 0.8 g/kg malathion. 100 mg/kg royal jelly was administered to MAL + RJ group rats via gavage 1 hour after the injection of 0.8 g/kg malathion. It was found that erythrocyte, liver, kidney and brain MDA concentrations were statistically significantly higher in MAL groups when compared to the others (p <0.05). It was observed that GSH concentrations increased in the brain, while they decreased in erythrocyte, liver and kidney in the MAL group when compared to the control and sham groups. CAT concentration significantly decreased significantly in erythrocyte, liver, kidney and brain in the MAL group when compared to the control and sham groups (p <0.05). SOD concentration in the MAL group decreased significantly (p <0.05) when compared to other groups, while SOD concentration increased significantly in the therapeutic and preventive groups (p < 0.05) when compared to the others. It was found that serum acetylcholinesterase (AChE) concentration was significantly lower in the MAL group when compared to sham and control groups (p <0.05). Thus, it was demonstrated that malathion led to lipid peroxidation and oxidative stress among MDA and NO levels and toxicity among AChE activities. It was also determined that royal jelly could be effective against oxidative damage and toxicity. The findings suggested that the antioxidant action of royal jelly could support the treatment of malathion, which is among the insecticides that contain organophosphate and lead to oxidative stress.
antioxidant, malathion, organophosphate, oxidative stress, royal jelly