In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia

 
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2011 (EN)

In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia (EN)

Παπουτσογλου Γεωργιος (EL)
Αναστασοπουλου Αγγελικη (EL)
Σταυρακακης Γεωργιος (EL)
Anastasopoulou Angeliki (EN)
C. Balas (EN)
Papoutsoglou Georgios (EN)
Stavrakakis Georgios (EN)
P. Souter (EN)

Πολυτεχνείο Κρήτης (EL)
Technical University of Crete (EN)

We present a method for detecting and studying neoplasia-specific functional and structural features through the combination of in vivo dynamic imaging, in silico modeling and global sensitivity analysis. We particularly present the case of cervical epithelium interacting with acetic acid solution, which is employed as an optical biomarker. The in vivo measured dynamic scattering characteristics are strongly correlated with the output of the biomarker's pharmacokinetic model that we have developed. Model global sensitivity analysis has shown that the measured/modeled bio-optical processes can be used for probing, in vivo, the number of neoplastic layers, the extracellular pH, the intracellular buffering efficiency and the size of the extracellular space. (EN)

conferenceItem
poster

Medicine (EN)


33rd Annual International Conference of the IEEE EMBS (EL)

English

2011





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