Exposure to compounds with dioxin-like activity in pregnant women, maternal dietary patterns and anogenital distance-mother-child cohort in Crete

This item is provided by the institution :

Repository :
E-Locus Institutional Repository
see the original item page
in the repository's web site and access all digital files if the item*

2009 (EN)
Έκθεση εγκύων γυναικών σε διοξίνες και μόρια με παρόμοια δράση, διατροφή κατά την εγκυμοσύνη και πρωκτογεννητική απόσταση των απογόνων τους-μελέτη μητέρας-παιδιού στην Κρήτη
Exposure to compounds with dioxin-like activity in pregnant women, maternal dietary patterns and anogenital distance-mother-child cohort in Crete

Παπαδοπούλου, Ελένη-Ζουμπουλιά

Κογεβίνας, Εμμανουήλ

BACKGROUND: Dioxins and dioxin-like compounds bioaccumulate through the food chain and act as endocrine disruptors. Nutrition during pregnancy has been assessed as the main route of in-utero exposure to these compounds, affecting birth outcome and parameters, as anogenital distance of the infant. OBJECTIVES: The aims of this study were to develop and implement a protocol for the measurement of anogenital distances in infants and to evaluate the association between maternal fat intake and anogenital distance in male and female infants. The association of mother‟s exposure to dioxin-like compounds with fat intake during pregnancy was also examined in a subsample. METHODS: A pilot study was conducted and comprised of 9 infants. In the current study we measured anogenital distance for 305 infants (158 males and 147 females), 0 to 16 months old. Dietary information was obtained for their mothers, participating in the mother-child cohort study. Measurements were associated with maternal fat intake for 150 mother-child pairs. RESULTS: In the total study population a negative correlation was found between maternal fat intake and anogenital distances, but results were statistically significant only for anogenital distance (AGD), anoscrotal distance (ASD) and penis width (PW) in males. Among newborns, women with high fat intake during pregnancy had more possibilities to give birth to an infant with a phenotype of short anogenital distance regardless of sex, after controlling for maternal and pregnancy related factors. CONCLUSION: Maternal fat intake during pregnancy that could be related to a higher uptake of endocrine disruptors was associated with shorter anogenital distances in males. Further analyses with a larger sample and the use of biomarkers are needed. (EN)

Τύπος Εργασίας--Μεταπτυχιακές εργασίες ειδίκευσης

Μελέτη Ρέα
Endocrine disruptors
Μελέτη μητέρας- παιδιού
Ορμονικοί διαταράκτες
Nutritional Physiological Phenomena
Mother-child cohort
Δράση παρόμοιων διοξινών
Πρόσληψη λίπους
Fat intake
Πρωκτογεννητική απόσταση
Rhea study
Ενδομήτρια έκθεση
Anogenital diastance
Dioxin-like activity



Σχολή/Τμήμα--Ιατρική Σχολή--Τμήμα Ιατρικής--Μεταπτυχιακές εργασίες ειδίκευσης

*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)