Βιοϊατρικές εφαρμογές μη γραμμικής λιθογραφίας

 
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2011 (EL)
Biomedical applications via nonlinear lithography
Βιοϊατρικές εφαρμογές μη γραμμικής λιθογραφίας

Μελισσινάκη, Βασιλεία

Φωτάκης, Κωνσταντίνος
Φαρσάρη, Μ

In the past few years, direct laser writing technology has been extensively studied, due to its ability for direct fabricating of complex 3D structures, which scale varies from several nanometers to some millimeters. This technology is based on nonlinear lithography and specifically, on twophoton polymerization process induced with a femtosecond laser. In this thesis, two-photon polymerization process was used for creating scaffolds with photosensitive biomaterials, for biomedical applications. In the first part, the 3D scaffolds’ fabrication using photosensitive, non-biodegradable materials has been investigated. The ability to develop 3D cell cultures on these scaffolds for tissue engineering applications has also been studied. Tissue engineering is a technology based on developing biological substitutes for the repair, reconstruction, regeneration or replacement of tissue. In this study, two organic-inorganic hybrid photosensitive sol-gel materials were used; a Zirconium based and a Titanium based material. The next step after the successful results of fibroblast cultivation on 2D thin films, was the fabrication of 3D complex porous structures, with the same materials and by using the same process of cultivation, inspiring results were given. In the second part, a new biodegradable polylactide-based material was used for fabricating tissue engineering scaffolds. In cooperation with the Kroto Research Institute and specifically the Department of Materials Science and Engineering of University of Sheffield, where the material was synthesized, neuronal cells (cell line PC12), as well as fibroblast cells (cell line 3T3), were cultivated on two dimensional thin films for checking the cells viability and proliferation and after the encouraging biocompatibility results, 3D complex porous structures were fabricated. The cells cultivation on the 3D scaffolds had successful results. (EN)

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Τύπος Εργασίας--Μεταπτυχιακές εργασίες ειδίκευσης

Καλλιέργεια Κυττάρων
Διφωτονικός πολυμερισμός
Cells cultivation
Two photon polymerization

Πανεπιστήμιο Κρήτης (EL)
University of Crete (EN)

Αγγλική γλώσσα

2011-11-18


Σχολή/Τμήμα--Σχολή Θετικών και Τεχνολογικών Επιστημών--Τμήμα Φυσικής--Μεταπτυχιακές εργασίες ειδίκευσης



*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.