Insulin-like growth factor system and inflammatory bowel disease

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Report (EN)

2007 (EN)
Insulin-like growth factor system and inflammatory bowel disease (EN)

Tsianos E.V.,
Katsanos K.,

SUMMARY Few reports concerning the levels and the importance of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the serum of patients with inflammatory bowel disease (IBD) have been published. Insulin-like growth factor(IGF) system has properties that are potentially relevant to IBD. The IGF system is a system complex composed of IGF-I and IGF-II as well as at least six different IGF binding proteins (IGFBP).IGF-I expression has been shown in lymphocytes, macrophages and fibroblasts. IGF-I is a potent mitogen for fibroblasts and smooth muscle cells and induces collagen synthesis in vitro, appearing to be important in tissue remodeling and repair. Proinflammatory cytokines such as interleukin-1 (IL- 1) may play a role in IGF-I production linking the IGF system with the inflammatory process in IBD patients. It has been suggested that IBD patients may have low IGF-I and IGFBP levels. In recent years the effect of regulatory peptides such as growth hormone (GH) and IGF-I in intestinal growth and repair has been emphasized. Trials of growth hormone in combination with a high-protein diet in short bowel syndrome patients as well as Crohn’s disease (CD) patients have been encouraging. It has been suggested that the IGF and IGFBP system may be abnormal in IBD patients during this chronic inflammatory process, yet there is no data is on the exact impact of inflammation on this down-regulation and the interaction between the interleukins and the IGF and IGFBP system, in IBD patients. Key words: IGF system, IGF-I, IGF-II, IGFBP3, IGFBP, inflammatory bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC). (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 15, No 1 (2002) (EN)

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