From the “hungry acid” to pepsinogen: a journey through time in quest for the stomach’s secretion

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Ελληνική Γαστροεντερολογική Εταιρία
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Annals of Gastroenterology
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Σημασιολογικός εμπλουτισμός/ομογενοποίηση από το EKT

2012 (EL)
From the “hungry acid” to pepsinogen: a journey through time in quest for the stomach’s secretion (EN)

Tsoucalas, Gregory; History of Medicine Department, Medical School, University of Athens, Greece
Armenis, Iakovos; History of Medicine Department, Medical School, University of Athens, Greece
Marineli, Filio; History of Medicine Department, Medical School, University of Athens, Greece
Kousoulis, Antonis A.; History of Medicine Department, Medical School, University of Athens, Greece
Karamanou, Marianna; History of Medicine Department, Medical School, University of Athens, Greece
Androutsos, George; History of Medicine Department, Medical School, University of Athens, Greece

The stomach’s secretion has been a mystery for centuries. Even after the first indications of its function and role appeared, every formulated idea on the nature of the gastric liquid remained open to controversy. After the ancient Greek perceptions which identified acids as bitter-sour liquids, the physicians of the Iatrochemical School, under the influence of Paracelsus and the alchemists, were the first to point out the physiologic chemistry of secretion. Experiments on animals and humans during the 17th-18th centuries, which mainly included swallowing various substances and observing the process, enhanced knowledge, with Stevens and Spallanzani playing the leading part. Any existing objections ceased in 1823, when Prout clearly identified hydrochloric acid as the acid agent of the stomach. Later on, the role of pepsin and pepsinogen was also judged to be important in digestion. In addition, the tremendous contribution of French scientists, experienced in the science of nutrition, must not be underestimated. It took centuries of research, and the involvement of many notable figures from many nations and countries, to form modern concepts of gastric secretion.Keywords stomach, hydrochloric acid, William Prout, Paracelsus, Lazzaro SpallanzaniAnn Gastroenterol 2012; 25 (2): 119-122 (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2012-04-11


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 25, No 2 (2012); 119 (EN)



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