Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9

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Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9 (EN)

Nguyen, Justin H.
Endo, Kosuke
Uemoto, Shinji
Baine, Ann-Marie T.
Jobara, Kanta
Kato, Takuma
Kuribayashi, Kagemasa
Gardner, Lindsay B.
Chen, Feng
Hori, Tomohide
Saito, Kanako
Torii, Mie
Wang, Linan
Sulistiono, Beni
Hata, Toshiyuki

Background Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue.Materials and Methods We used a rat model to examine MMP-9 expression 6 h after  laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group.Results The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159).Conclusion Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.Keywords extended hepatectomy, Pringle maneuver, remnant liver, split liver transplantation, small-for-size graft (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2012-10-14


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 25, No 4 (2012); 345 (EN)



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