Innate immunity: a new chapter for hepatitis C
Khakoo, Salim I.
The immune response to hepatitis C virus (HCV) and the mechanisms leading to successfulresolution are complex. Much work has been done on understanding the adaptive immuneresponse to HCV due to the imperative of trying to find a vaccine. However the importanceof the innate immune system is being increasingly recognized. This has culminated in thediscovery of IL-28B as a key genetic element in recovery from HCV in diverse populations.This association is one of the strongest in anti-viral immunity and represents a paradigm shiftin how we view the immune response to HCV infection.Keywords Hepatitis C, immunity, innate, interleukinsAnn Gastroenterol 2012; 25 (2): 232-240