Co-administration of granulocyte colony-stimulation factor allows completion of interferon therapy in chronic viral hepatitis with neutropenia

 
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2007 (EN)
Co-administration of granulocyte colony-stimulation factor allows completion of interferon therapy in chronic viral hepatitis with neutropenia (EN)

Patsanas Th.,
Rapti E.,
Tzilves D.,
Kokozidis G.,
Kitis G.,

SUMMARY Neutropenia, due either to hypersplenism or to myelotoxicity of interferon (IFN), is a contraindication to start or continue IFN treatment. In a prospective, open study the use of granulocyte colony stimulating factor (G-CSF), a growth factor capable of directly and selectively stimulating proliferation, differentiation and function of neutrophils, has been evaluated in combination with IFN A-2a in patients with chronic viral hepatitis. Inclusion criteria, in addition to those for IFN treatment, were compensated disease (Child-� class A), leukocyte count< 3,0 k/�l and/or neutrophil count < 1,5 k/�l. The dose of G-CSF was titrated in order to raise and maintain the white cell counts above these levels throughout the treatment period and limited to (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 15, No 1 (2002) (EN)



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