Gastroenteropancreatic neuroendocrine tumors: diagnosis and treatment

 
This item is provided by the institution :

Repository :
Annals of Gastroenterology
see the original item page
in the repository's web site and access all digital files if the item*
share




2012 (EN)

Gastroenteropancreatic neuroendocrine tumors: diagnosis and treatment (EN)

Díez, Marc
Salazar, Ramon
Teulé, Alexandre

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively rare and complex neoplasms that present many clinical challenges. Most GEP-NETs are sporadic, but they can be multiple and a component of a familial syndrome. Assessment of the location and extent of GEP-NETs is crucial for management and a number of novel imaging modalities are under evaluation with the principal goal of increasing sensitivity for the detection of micro-metastases while retaining specificity. The appropriate diagnosis and treatment of neuroendocrine tumors often involves collaboration between specialists in multiple disciplines, using specific biochemical, radiologic, and surgical methods. Management strategies include surgery, radiological intervention, cytotoxic chemotherapies, somatostatin analogs and novel biological agents such as sunitinib and everolimus. Other biological agents, new chemoteraphy regimens and somatostatin-tagged radionuclide therapies are also under investigation. In spite of this, comparison between therapeutic modalities is currently difficult. Further studies are warranted to individualize and optimize the diagnosis and treatment of these tumors.Keywords Gastroenteropancreatic neuroendocrine tumors, targeted drugs, PET, everolimus,sunitinib (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion


English

2012-12-21


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 26, No 1 (2013); 29 (EN)




*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)