Patients with refractory gastroesophageal reflux disease: diagnostic tools
Karamanolis, Georgios P.
Patients with refractory to proton pump inhibitors (PPIs) gastroesophageal reflux disease(GERD) symptoms are approximately 40% and represent a very common problem in clinicalpractice. Many of these patients do not have GERD, but suffer from functional heartburn orhypersensitive esophagus. After thorough clinical evaluation and failure of escalation of PPIdose, diagnostic investigations include endoscopy, esophageal manometry, pH testing, esophagealBilitec and esophageal impedance with pH monitoring.Keywords Refractory GERD, diagnosis