Distinction between patients with non-erosive reflux disease and functional heartburn

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Ελληνική Γαστροεντερολογική Εταιρία
Αποθετήριο :
Annals of Gastroenterology
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Σημασιολογικός εμπλουτισμός/ομογενοποίηση από το EKT

2013 (EL)
Distinction between patients with non-erosive reflux disease and functional heartburn (EN)

Giacchino, Maria; Gastroenterology Unit Department of Internal Medicine University of Genoa, Viale Benedetto XV, 6 16132 Genoa, Italy
Savarino, Edoardo; Gastroenterology Uniy Department of Surgery, Oncology and Gastroenterology University of Padua Via Giustiniani 2 35128 Padua, Italy Tel.: 0039-049-8217749 Fax.: 0039-010-3538956 Email: edoardosavarino@gmail.com
Savarino, Vincenzo; Gastroenterology Unit Department of Internal Medicine University of Genoa, Viale Benedetto XV, 6 16132 Genoa, Italy

None (EN)

Non-erosive reflux disease (NERD) and functional heartburn (FH) are two different clinical entities and the clear distinction between the two forms is actually possible thanks to the use of impedance-pH monitoring. NERD is the more common manifestation of gastro-esophageal reflux disease (GERD), one of the most widespread chronic gastrointestinal disorders in Western countries. The absence of visible lesions on endoscopy and the presence of troublesome reflux-associated (to acid, weakly acidic or non-acid reflux) symptoms are the two key factors for the definition of NERD. FH is an exclusive diagnosis and is defined by the Rome III criteria as a burning retrosternal discomfort, excluding GERD and esophageal motility disorders as a cause of the symptom. FH does not have any type of reflux underlying symptoms and psychologicalfactors  seem to be more expressed in FH patients than in patients with reflux-provoked disturbances. The aim of our review is to report the state-of-the-art knowledge about NERD and FH, to clarify their features and differences and to stimulate new research in this field.Keywords Non-erosive reflux disease, functional heartburn, gastro-esophageal reflux disease, esophageal impedance-pH monitoring, PPI (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2013-09-30


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 26, No 4 (2013); 283 (EN)



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