Helicobacter pylori infection in patients with liver cirrhosis: prevalence and association with portal hypertensive gastropathy

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Το τεκμήριο παρέχεται από τον φορέα :
Ελληνική Γαστροεντερολογική Εταιρία
Αποθετήριο :
Annals of Gastroenterology
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Σημασιολογικός εμπλουτισμός/ομογενοποίηση από το EKT

2013 (EL)
Helicobacter pylori infection in patients with liver cirrhosis: prevalence and association with portal hypertensive gastropathy (EN)

Sreesh, Srijaya; Assistant Professor,Department of Medical Gastroenterology, Government Medical College,Thiruvananthapuram
Abdul Sathar, Shanid; Senior Resident, Department of Medical Gastroenterology, Government Medical College,Thiruvananthapuram
Vinayakumar, Kattoor Ramakrishnan; Professor,Department of Medical Gastroenterology, Government Medical College,Thiruvananthapuram
Kunnathuparambil, Sojan George; Senior Resident, Department of Medical Gastroenterology, Government Medical College,Thiruvananthapuram
Narayanan, Premaletha; Additional Professor,Department of Medical Gastroenterology, Government Medical College,Thiruvananthapuram

Background The role of Helicobacter pylori (H. pylori) in the pathogenesis of portal hypertensive gastropathy (PHG) in cirrhotic patients is poorly defined. The aim of this study was toinvestigate the prevalence of H. pylori infection and its association with PHG in patientswith liver cirrhosis.Methods Seroprevalence of H. pylori was tested in 70 cirrhotic patients with PHG (cases) and 70 cirrhotic patients without PHG (controls) using an anti-H. pylori IgG ELISA. All patients underwent upper gastrointestinal endoscopy to assess the severity of PHG and grade of varices.Results The presence of H. pylori was observed in 31 (44.3%) cirrhotic patients with PHG (cases) compared to 19 (27.1%) cirrhotic patients without PHG (controls). The risk estimate showed a significant association between H. pylori and PHG in cirrhotic patients (P=0.034, OR 2.134, 95% CI 1.052-4.327). Out of the 31 patients with PHG and H. pylori infection, 19 had severe PHG and 12 had mild PHG while 5 patients had severe PHG and 34 had mild PHG in the group of H. pylori negative patients. The difference was statistically significant (P<0.001, OR 10.767, 95% CI 3.293-35.205). Of the 70 patients with PHG, 24 had severe PHG and of these 18 (75%) were in Child C compared to 6 (25%) in Child B.Conclusion There is significant association between H. pylori infection and PHG in cirrhotic patients which is also related to severity of PHG. Thus, H. pylori needs to be eradicated in cirrhotic patients with PHG.Keywords Portal hypertensive gastropathy (PHG), Helicobacter pylori (H. pylori), cirrhosisAnn Gastroenterol 2014; 27 (1): 48-52 (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2013-12-19


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 27, No 1 (2014); 48 (EN)



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