Gut motility and visceral perception in IBS patients

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2007 (EN)
Gut motility and visceral perception in IBS patients (EN)

., A. Mantides

SUMMARY Although IBS is the most common functional disorder of alimentary tract in western countries, its pathogenesis is still not fully understood. It seems that multiple precipitating factors alter gut motility and visceral perception, resulting in specific motor function disorders. These disorders seem to differ between patients presenting with constipation and those presenting with diarrhea. The most common motility disorders found in IBS patients include the frequency of high amplitude propagating contractions (HAPC), the contractile activity of rectosigmoid, and the motor function changes after ingestion of food. The presence of a generalized alimentary tract motility disorder in IBS, suggests the presence of a systematic neuromuscular dysfunction. In two-thirds of patients, a disturbance in visceral perception and visceral hypersensitivity as a response to either normal, or abnormal stimuli, exists. Despites the fact that the actual mechanisms responsible for these disorders are, as yet, partially unknown, there is a body of evidence that a brain-gut axis dysfunction, further impaired by psychological stress, may be the leading cause of IBS. Key words: Irritable bowel syndrome, gastrointestinal motility, visceral hypersensitivity, visceral perception (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 15, No 3 (2002) (EN)

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