Indolent systemic mastocytosis in a patient with ileocolitis

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Indolent systemic mastocytosis in a patient with ileocolitis (EN)

Mylonas, Georgios
Koutsoumpas, Andreas
Papasavvas, Stelios
Demonakou, Maria
Tzias, Vassilios
Chrysakopoulos, Georgios

Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor cell. It is a rare disorder with unknown incidence in Greece, with an estimate of 2 cases per year in Great Britain. We present a case of an asymptomatic, 72-year-old man who was found to have ileocolitis on endoscopy. Histology revealed mast cells in lamina propria >15 HPF and biochemistry showed high levels of serum total tryptase. Molecular testing was positive for the mutation Asp816Val in exon 17 of c-kit gene. The patient met one major and two minor criteria for the diagnosis of systemic indolent mastocytosis (according to WHO classification). He has been treated prophylactically with H1- and H2-histamine receptor antagonists and remains asymptomatic.Keywords Mastocytosis, indolent, asymptomatic, colitis, ileitisAnn Gastroenterol 2014; 27 (3): 270-272 (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2014-06-28


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 27, No 3 (2014); 270 (EN)



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