Genetic markers and the classification of Inflammatory Bowel Disease

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Annals of Gastroenterology
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Report (EN)

2007 (EN)
Genetic markers and the classification of Inflammatory Bowel Disease (EN)

A.S. Peña, G. Bouma,

SUMMARY Crohn’s disease and ulcerative colitis are common causes of gastrointestinal morbidity in the Western World. The exact aetiology is unknown, yet, it is generally accepted that disease occurs as the consequence of dysregulated immune response to one or more exogenous factors in a genetically predisposed host. Epidemiological, family, association, and human genome screening studies have provided overwhelming evidence for a genetic susceptibility to IBD. These studies clearly indicate that IBD is not inherited as a simple Mendelian disorder, but more likely as a complex genetic trait, including gene-gene and gene-environment interactions. Recently, significant progress has been accomplished in understanding the immunological mechanisms that mediate chronic intestinal inflammation, as well as in identifying the genetic abnormalities that underlie these pathologic inflammatory responses. In the current review, we will focus on recent developments in unravelling the genetic basis of IBD and we will discuss the potential clinical applications of these findings. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 15, No 4 (2002) (EN)

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