First- and second-line Helicobacter pylori eradication with modified sequential therapy and modified levofl oxacin-amoxicillin-based triple therapy

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First- and second-line Helicobacter pylori eradication with modified sequential therapy and modified levofl oxacin-amoxicillin-based triple therapy (EN)

Efrati, Cesare
Alvaro, Domenico
Zullo, Angelo; "Nuovo Regina Margherita" Hospital
De Francesco, Vincenzo
Ridola, Lorenzo
Nicolini, Giorgia
Giorgio, Floriana
Cannaviello, Claudio
Gatta, Luigi
Hassan, Cesare

Background Helicobacter pylori (H. pylori) treatment remains a challenge for physicians. Although highly effective, the standard sequential therapy fails in a certain number of patients. Moreover, the curerate following a levofloxacin-amoxicillin second-line triple therapy seems to be decreasing. We tested the efficacy of modified 10-day sequential therapy, and an intensified levofloxacin-amoxicillin regimen as first- and second-line therapy respectively.Methods In this prospective, open label, multicenter, pilot study H. pylori-infected patients received a first-line modified 10-day sequential therapy regimen including rabeprazole 20 mg, and amoxicillin 1 g for the first 3 days, followed by rabeprazole 20 mg, clarithromycin 250 mg, and metronidazole 250 mg, for the remaining 7 days, all drugs given thrice daily. An 8-day therapy regimen with rabeprazole 20 mg, levofloxacin 250 mg, and amoxicillin 1 g, all thrice daily, was administered a second-line therapy.Results A total of 99 and 15 patients were enrolled for first- and second-line therapy. The eradication rates were 85.9% (95% CI 80-93) and 93.4% (95% CI 88-98) according to ITT and PP analyses following modified sequential therapy, and 60% (95% CI 35-86) and 64.3% (95% CI 39-89) following the intensified second-line therapy.Conclusion A modified sequential 3- plus 7-day regimen with thrice daily drug administration failed to achieve very high eradication rate at ITT analysis. The intensified second-line  regimen achieved disappointingly low eradication rate. Novel levofloxacin-free second-line therapies are urged in Italy.Keywords Helicobacter pylori, therapy, sequential therapy, modified sequential therapy, secondline therapy, modified levofloxacin triple therapyAnn Gastroenterol 2014; 27 (4): 357-361 (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2014-10-02


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 27, No 4 (2014); 357 (EN)



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