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Report (EN)

2007 (EN)
The pathogenesis of Helicobacter pylori infection (EN)

Christine Bergele, A. Avgerinos, S.N. Sgouros,

SUMMARY It is well established that the presence of Helicobacter pylori in the gastric mucosa is associated with chronic active gastritis and is implicated in more severe gastric diseases, including chronic atrophic gastritis (a precursor of gastric carcinomas), peptic ulceration and mucosa-associated lymphoid tissue lymphomas. On the other hand, it is well recognized that only a minority of infected individuals develop severe inflammation leading to peptic ulcer or gastric cancer. In an effort to evaluate the factors that could determine the clinical outcome of infection, investigators focused on virulence factors of the organism, but substantial data failed to support this model. In the present study we tried to overview the mechanisms involved in the pathogenesis of Helicobacter pylori infection in humans, emphasizing the factors which are likely to be more crucial in disease progression to peptic ulcer disease, MALT lymphomas and gastric cancer. It seems likely that other host–derived and environmental factors are more significant in determining clinical outcome but additional studies are needed in order to clarify the underlying mechanisms involved in the clinical outcome of infection. Key words: Helicobacter pylori, gastritis, gastric cancer, MALT lymphoma, peptic ulcer (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 16, No 2 (2003) (EN)

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