Genome-wide Search for Chromosomal Aberrations in Colorectal Cancer: Implications for Pathogenesis and Clinical Management

 
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Annals of Gastroenterology
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Genome-wide Search for Chromosomal Aberrations in Colorectal Cancer: Implications for Pathogenesis and Clinical Management (EN)

Sverre Heim, Georgia Bardi,

SUMMARY In the present review, we discuss the cytogenetic findings we have made in karyotyping studies of colorectal cancer examined during a 10-year-period at two Scandinavian institutions (Lund University Hospital, Sweden and Odense University Hospital, Denmark) as well as relevant findings by comparative genome hybridization (CGH) since this method too provides a global overview of genomic alterations. Our total series consists of 280 cytogenetically investigated colorectal tumors, of which 82 were benign lesions (mostly adenomas), 162 were primary carcinomas, and 36 were metastases. The cytogenetic studies of these tumors enabled us to: 1. identify early, possibly initiating, genetic events in colorectal tumorigenesis; 2. determine the clonal relationship among synchronously growing, macroscopically distinct colorectal adenomas as well as between carcinomas and polyps growing in the same patients; and 3. describe the cytogenetic make-up of metastatic lesions by comparing karyotypically primary tumors and their local and distal metastases in individual patients. The correlation of tumor karyotypes with clinicopathologic parameters in the series, enabled us to demonstrate considerable genetic heterogeneity in colorectal tumors with distinct cytogenetic subgroups corresponding to at least two oncogenetic pathways in sporadic large bowel cancer, as is known to be the case also in hereditary colorectal tumors. Finally, the karyotypic pattern could provide valuable and in some instances unique information about the prognosis of colorectal cancer patients and, hence, clues as to how they should best be treated. (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 16, No 3 (2003) (EN)



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