New Trends in Early Detection of Colorectal Cancer

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Annals of Gastroenterology
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2007 (EN)
New Trends in Early Detection of Colorectal Cancer (EN)

K. Tsamakidis, E. Paraskevas, D. Dimitroulopoulos, D. Xinopoulos,

SUMMARY Current practice guidelines recommend annual fecal occult blood-test screening for colorectal cancer in the averagerisk population over the age of 50. Efficacy of fecal occult blood-test screening is supported by several recent, controlled, prospective trials and case-control studies. On the other hand, a new generation of fecal tests based on immunocytochemical and RT-PCR methods recently has been developed. There is strong evidence that colon screening of asymptomatic, average-risk subjects can reduce colorectal cancer mortality. Endoscopic screening with sigmoidoscopy can reduce mortality associated with left-sided cancers due to discovery of early curable cancers and the detection and removal of premalignant adenomas. But, with this technique, only the superficial mucosa is visua-lized and at relatively low magnification. Thus, new imaging systems, based on light-tissue interactions, such as optical coherence tomography, light-induced fluorescence spectroscopy, time-resolved fluorescence, light-scattering spectroscopy, chromoendoscopy and magnification endoscopy are being developed to advance endoscopic diagnosis of colorectal cancer. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 16, No 3 (2003) (EN)

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