Serum levels of ghrelin and obestatin in children with symptoms suggestive of delayed gastric emptying of unclear etiology

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Ελληνική Γαστροεντερολογική Εταιρία
Αποθετήριο :
Annals of Gastroenterology
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Σημασιολογικός εμπλουτισμός/ομογενοποίηση από το EKT

2015 (EL)
Serum levels of ghrelin and obestatin in children with symptoms suggestive of delayed gastric emptying of unclear etiology (EN)

Iakovou, Ioannis; 3rd Nuclear Medicine Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece
Farmaki, Evangelia; 1st Pediatric Department, Ippokratio Hospital, Aristotle University, Thessaloniki, Greece
Saliakellis, Efstratios; 4th Pediatric Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece
Varlamis, Georgios; 4th Pediatric Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece
Karatzas, Nikolaos; 3rd Nuclear Medicine Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece
Fotoulaki, Maria; 4th Pediatric Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece

Background Ghrelin and obestatin are peptides of the gut-brain axis affecting appetite and gastrointestinal motility.Methods We conducted a cross-sectional, case-control study to determine pre- and postprandial serum levels of total ghrelin and obestatin along with gastric emptying scintigraphy in children with  symptoms suggestive of delayed gastric emptying time (GET), not attributable to any identifi able cause.Results Twenty children with symptoms suggestive of delayed GET, of whom 9 had delayed GET, and 20 age-matched healthy children were enrolled. Preprandial ghrelin and obestatin were higher compared to controls (GHR mean level in patients and controls: 1162 pg/mL and 401 pg/mL respectively; P<0.05; OB mean level in patients and controls: 417 pg/mL and 325 pg/mL respectively; not statistically signifi cant). Postprandial ghrelin was signifi cantly decreased in the subgroup of patients with delayed GET (GHR mean level in children with normal and prolonged GET: 1237 pg/mL and 584 pg/mL respectively; P<0.05).Conclusion Obestatin and ghrelin were deranged in children with symptoms indicative of delayed GET of unexplained etiology. Gastric emptying was prolonged in almost half of the patients thus gastric emptying scintigraphy should be considered in the investigation of children with such symptomatology.Keywords Children, ghrelin, obestatin, delayed gastric emptying, gastric emptying scintigraphyAnn Gastroenterol 2015; 28 (4): 452-456 (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2015-10-01


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 28, No 4 (2015); 452 (EN)



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