Boceprevir for chronic HCV genotype 1 infection in treatmentexperienced patients with severe fibrosis or cirrhosis: The Greek real-life experience

 
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Annals of Gastroenterology
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Τμήμα περιοδικού (EL)
2015 (EL)
Boceprevir for chronic HCV genotype 1 infection in treatmentexperienced patients with severe fibrosis or cirrhosis: The Greek real-life experience (EN)
Goulis, John
Papatheodoridis, George
Kranidioti, Hariklia
Koulentaki, Mairi
Sinakos, Emmanouel
Elefsiniotis, John
Evangelidou, Eftychia
Vafiadou, Irini
Vlachogiannakos, John
Doumba, Polyxeni
Kouroumalis, Elias A.
Akriviadis, Evangelos
Koskinas, John
Kontos, George
Manolakopoulos, Spilios
Background The aim of our study was to evaluate the safety and efficacy of triple therapy using boceprevir (BOC) with pegylated interferon (pIFN)/ribavirin (RBV) in chronic hepatitis C (CHC) genotype 1 (G1) treatment-experienced patients with advanced fibrosis or compensated cirrhosis.Methods We report the Greek experience on the first CHC patients who received BOC-based regimen. From September 2011 to June 2012, 26 treatment-experienced CHC patients and G1 with bridging fibrosis or compensated cirrhosis received 48 weeks of BOC+pIFN+RBV antiviral therapy. Data on complete blood counts and HCV RNA levels were obtained prior to therapy, at treatment weeks 4, 8, 12, 24, 36, 48 and 24 weeks aft er the end of treatment.Results A full set analysis was performed in 25 of 26 patients. Nine patients (36%) achieved sustained viral response (SVR). Ten patients (40%) stopped the therapy because of futility rules and 3 (12%) due to adverse events. Four patients (16%) developed a virological breakthrough (3 of those presented futility rules as well) and 2 (8%) relapse. All patients who achieved SVR had G 1b, 6 (67%) were non-cirrhotic and 5 (55%) had >1 log decline in baseline HCV RNA levels at week 4 of the treatment. There were no deaths, while two patients were hospitalized due to side effects.Conclusion The triple therapy with BOC+pIFN+RBV in this cohort of real-life  treatmentexperienced CHC G1 patients and advanced liver disease was safe offering cure in the majority of those who could tolerate and complete treatment under a close monitoring.Keywords Protease inhibitors, boceprevir, HCV G1 infectionAnn Gastroenterol 2015; 28 (4): 481-486 (EN)
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Ελληνική Γαστροεντερολογική Εταιρία
Annals of Gastroenterology
Αγγλική γλώσσα
2015-09-25
http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2247
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 28, No 4 (2015); 481 (EN)



*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.