Inflammatory bowel disease: can omega-3 fatty acids really help?

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Inflammatory bowel disease: can omega-3 fatty acids really help? (EN)

Quesada, Karina; Department of Nutrition, School of Medicine, University of Marília, Higino Muzzi Filho Avenue, 1001, Marília – SP- Brazil
Goulart, Ricardo de Alvares; Medical Doctor, Department of Gastroenteology, University Hospital - UNIMAR, Higino Muzzi Filho Avenue, 1001 - Marília – SP- Brazil
Bechara, Marcelo Dib; Department of Biochemistry and Genetics, School of Medicine, University of Marília, Higino Muzzi Filho Avenue, 1001, Marília – SP – Brazil
Barbalho, Sandra Maria; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília and Food Technology School (FATEC), Higino Muzzi Filho Avenue, 1001, Marília – SP- Brazil
Carvalho, Antonely de Cássio Alves de; Medical Doctor from Diagnostic Center in Gastroenterology, Arthur Sampaio Street, 140, Ibaiti – PR- Brazil

Adjuvants to the traditional therapy of infl ammatory bowel disease (IBD) have been studied to enhance the effi cacy of the treatment and improve patients’ quality of life. Omega-3 polyunsaturated fatty acids (ω3FA) have been associated with attenuation of the inflammatory responses in IBD, possibly acting as substrates for anti-inflammatory eicosanoid production, similar to prostaglandins and leukotrienes. ω3FA also act as substrates for the synthesis of resolvins, maresins and protectins, indispensable in resolving infl ammation processes. These acids may infl uence the development or course of IBD by: reducing oxidative stress, production of tumor necrosis factor-α and proinfl ammatory cytokines; working as chemopreventive agents; and decreasing the expression of adhesion molecules. There are numerous controversies in the literature on the eff ects of ω3FA in the prevention or treatment of IBD, but their eff ects in reducing infl ammation is incontestable. Th erefore, more studies are warranted to elucidate the pathophysiological mechanisms and establish the recommended daily intake to prevent or induce remission in IBD patients.Keywords Ulcerative colitis, Crohn’s disease, omega-3 polyunsaturated fatty acidsAnn Gastroenterol 2016; 29 (1): 37-43 (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2016-01-08


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 29, No 1 (2016); 37 (EN)



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