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Report (EN)

2007 (EN)
Autoimmune liver disease (EN)

K. Goumas, D. Soutos, C. Petrogiannopoulos, K. Papamichael,

SUMMARY Autoimmunity is regarded as the main mechanism involved in pathogenesis of various liver diseases, such as autoimmune hepatitis (ÁIÇ), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), autoimmune cholangitis, overlap syndromes AIH-PBC and AIH-PSC and liver dysfunction due to connective tissue diseases1. Autoimmune hepatitis is an immune-mediated, autodestructive liver disease with hepatocytes being the target cells of the human immune system.2,8 Primary biliary cirrrhosis and primary sclerosing cholangitis are also regarded as autoimmune liver diseases with bile duct epithelia being the target cells, resulting in a continuous loss of bile ducts.3 These diseases may occur simultaneously in their full manifestations in about 10-20% of cases, thus constituting an overlap syndrome AIH-PBC or AIH-PSC.4 Key Words: Primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cirrhosis, overlap syndromes. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 17, No 1 (2004) (EN)

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