Is there a protective involvement of HLA-B35 in the development of pancreatic cancer and its pulmonary metastases?

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Annals of Gastroenterology
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Is there a protective involvement of HLA-B35 in the development of pancreatic cancer and its pulmonary metastases? (EN)

K.E. Tarassi, TH. Athanasiades, C.I. Fotiades, C.A. Papasteriades,G. Androulakis, I.A. Kouerinis, G. Zografos,

SUMMARY PURPOSE: Similar to findings obtained for most carcinomas, the pathogenesis of pancreatic cancer (PC) is considered to be multifactorial. Nowadays, there is a research into the contribution of genetic factors to the pathogenesis of cancer, including pancreatic. The present study was undertaken to investigate the protective role of human leukocyte antigens in a group of patients with pancreatic cancer, and also to correlate the findings with the development of metastatic disease in the lungs. Additionally, we searched for the protective role of HLA-B35, recognised worldwide in relation to several types of cancer. SUBJECTS AND METHODS: The allele frequencies of serologically defined human leukocyte antigen classes II and I were studied in 60 patients with a recent, histologically confirmed diagnosis of pancreatic cancer. All individuals in this study were unrelated to each other. Patients were also classified with regard to alcohol consumption, to the presence of non-insulin dependent diabetes mellitus and the presence of pulmonary metastatic disease. The results obtained for leukocyte frequencies were compared with those of 105 healthy control subjects (control group). Additionally, HLA frequencies of PC patients with sole pulmonary metastatic disease (7 subjects) were compared with those of the other patients (53 subjects). RESULTS: Among several HLA antigens that were identified in lower frequencies in PC patients compared with healthy individuals, HLA-B35 seemed to be the most likely to play a protective role, although statistically significant differences were marginal (21,7% in healthy individuals vs 36,8% in patients, P=0,056, OR=0,488). Furthermore, HLA involvement in the development of pulmonary metastatic disease in PC patients was not proved. CONCLUSION: Although recent observation of specific human leukocyte antigen associations with particular subsets of pancreatic cancer strongly suggested that genetic susceptibility for the development of pancreatic cancer exists, their protective role to the pathogenesis of the disease needs further investigation. On the other hand, no involvement of HLA system in the pulmonary metastatic development was finally identified. In conclusion, the multifactorial pathogenesis of pancreatic cancer must always be considered and human leukocyte antigens may show useful predictive and diagnostic value in the near future. Key words: HLA, pulmonary metastases, pancreatic cancer, genetic markers. (EN)


Αγγλική γλώσσα


Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 17, No 1 (2004) (EN)

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