Correlation between Epstein Barr Virus and early gastric cancer

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Annals of Gastroenterology
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2007 (EN)
Correlation between Epstein Barr Virus and early gastric cancer (EN)

Stefanidis S.,
Minopoulos G.,
Kouklakis G., .

SUMMARY Objective: The aim of this study was to explore the possible oncogenic role of Epstein Barr virus in early gastric cancer. Patients and methods: In eleven patients diagnosed with early gastric cancer, specific anti-EBV immunoglobulines were measured before and after their treatment. The possibility of Helicobacter Pylori infection was also considered and examined both with rapid urease test and haematoxylin ñŠ¥osin staining. Results: In nine patients the anti-EBV immunoglobulines tested out positive in very high titers before the treatment. In three of them the titers dropped to the usual titers detected in healthy individuals with past EBV infection, six months after the treatment. Helicobacter Pylori infection was detected in only three of the patients. Conclusion: Epstein Barr virus is probably a direct oncogenic factor in early gastric cancer. It is also possible that a geographic allocation exists regarding ití³ prevalence in different populations which could be explained by variations in HLA expression. Key words: Epstein Barr virus, early gastric cancer, Helicobacter pylori, oncogenesis (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 13, No 3 (2000) (EN)

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