Screening program on hepatitis B in young Albanian population: The Greek-Albanian collaborative study on the prevention of hepatitis B (the HEPAGA project)

 
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Annals of Gastroenterology
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Screening program on hepatitis B in young Albanian population: The Greek-Albanian collaborative study on the prevention of hepatitis B (the HEPAGA project) (EN)

Adriana Babameto, B. Craja, D. Christodoulou,G. Tsonis, B.F. Resuli, E.V. Tsianos, K.H. Katsanos, Eleftheria Zervou,

SUMMARY Aim: The aim of the study was to screen for hepatitis B virus (HBV) in a well-defined, young, population in the area of Tirana, Albania (the HEPAGA project). Patients-Method: This study was conducted under the auspices and with grants from the Greek Ministry of Development and the Albanian Ministry of Education and science. This collaborative study lasted for two years (2001- 2002) and was successfully completed on both sides. Serum samples from the non-vaccinated, young population (ages 14-20) living in a well-defined area of Tirana were collected during the period from September 2001 to February 2002 and were stored at -20o C until assayed at the Blood Bank of the Ioannina University Hospital. Every sample was examined for HBV immunology profile using routine methods. In case of gray zone results double testing was performed. In cases of insufficient serum we tested, in priority, HBsAg, then HBcore antibody (anti-) and then anti- HBs. Results were then sent back to Albania where Albanian Results: The Greek part received 412 serum samples. Two samples could not be evaluated for technical reasons, while the remaining 410 were analyzed for the HBV immunology parameters as shown below. Parameter tested No of % samples Hepatitis B virus not detected 226 54.88 HBsAg(+) 49 11.89 HBcore(+)/anti-HBs over 10 UI/ml 87 21.19 HBcore(+)/anti-HBs less than 10 UI/ml 14 3.49 Only HBcore(+) 14 3.49 HBcore(+) not enough serum for anti-HBs 8 1.97 HBsAg(-) not enough serum for HBcore 12 3.09 TOTAL 410 100.00 Conclusions: The HEPAGA Study showed that public health projects between Balkan countries are realistic. Albania is a paradigm of public health prevention strategy directed at the elimination of hepatitis B through an expanded, obligatory vaccination programme. Key words: hepatitis, HBsAg, Albania, Greece, screening, population study (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 17, No 2 (2004) (EN)



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