Viral hepatitis status does not affect survival in patients with hepatocellular carcinoma

 
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Annals of Gastroenterology
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Τμήμα περιοδικού (EL)
2016 (EL)
Viral hepatitis status does not affect survival in patients with hepatocellular carcinoma (EN)
O'Neill, Jacqueline
Caldwell, Katharine
Nir, Itzhak
Munoz Estrada, Oscar
Rodriguez, Rodrigo
Luo, Li
Greenbaum, Alissa
Morris, Katherine T.
Alkhalili, Eyas
Background There have been few studies on the impact of viral etiology on the prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to evaluate the clinical characteristics and survival of patients with viral hepatitis-associated HCC (V-HCC), compared to patients with HCC of non-hepatitis B, non-hepatitis C (NBNC-HCC) etiology.Methods We performed a retrospective analysis of all patients with HCC treated at our comprehensive cancer center from 2000 through 2014. Patients were divided into two groups according to their viral hepatitis status. Presentation patterns, treatments, and survival data were analyzed.Results We evaluated 366 patients: 233 patients (63.7%) had V-HCC while 133 (36.3%) patients had NBNC-HCC. V-HCC patients were younger (P<0.0001) and more likely to be male (P=0.001). Decompensated cirrhosis was more prevalent in V-HCC patients (P=0.01). There was no difference in the resectability rate or disease stage. In patients with resectable disease, those with V-HCC were less likely to undergo hepatectomy (23.7% vs. 38%; P=0.04) for more advanced liver disease. The estimated median survival for V-HCC was 13 months compared to 16 months in NBNCHCC patients (P=0.57). On multivariate analysis, disease stage (P<0.0001) and Child-Pugh class (P<0.0001) were independent factors affecting survival, but viral status was not (P=0.75).Conclusion Despite presenting with more advanced cirrhosis and being less likely to undergo surgery, V-HCC patients had similar survival to patients with NBNC-HCC.Keywords Hepatocellular carcinoma, survival, viral hepatitisAnn Gastroenterol 2017; 30 (1): 101-105 (EN)
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Ελληνική Γαστροεντερολογική Εταιρία
Annals of Gastroenterology
Αγγλική γλώσσα
2016-12-27
http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2972
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 30, No 1 (2017); 101 (EN)



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